THE MARSHALL LAB
Professor G. R. Marshall
The major focus of our lab is Molecular Recognition, which is the basis of intermolecular interactions and specificity seen in drug-receptor, hormone-receptor, antigen-antibody and substrate-enzyme systems. We use a variety of techniques to investigate these phenomena including: quantum chemistry, molecular mechanics, conformational analysis, molecular modeling and computer graphics for providing a theoretical basis of interaction, chemical synthesis for probing interactions and testing hypotheses, spectroscopy (NMR, EPR and FRET) for validating theoretical and experimental approaches, and bioassays for quantifying receptor interactions and assessing metabolism.
Current projects involve the role of co-receptors in the entry of HIV into cells; the role of reverse turns in the receptor-bound conformation of peptide hormones such as angiotensin; experimental and theoretical studies of G-protein coupled receptors and their interaction with G-proteins; and de novo prediction of protein structure and protein engineering.
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This website was last modified on: 08/31/06
©2006 by the Department of Biochemistry and Molecular Biophysics at Washington University School of Medicine.